Research Intern - Hematopoietic Biology & Malignancy (Dr. Molldrem's Lab)
- Requisition #: 710597-202504220935
- Department: Hematopoietic Biology&Malignan
- Location: Houston, TX
- Posted Date: 4/21/2025
A Research Intern position is available in the Department of Hematopoietic Biology and Malignancy at The University of Texas MD Anderson Cancer Center in Houston, TX. This position reports to Dr. Jeffrey J. Molldrem, Chair of the Department of Hematopoietic Biology and Malignancy. Dr. Molldrem's lab focuses on developing immunotherapies for leukemia and other hematologic diseases by understanding T-cell immunity against hematopoietic progenitors. Our central hypothesis is that T-cells target and eliminate these progenitors by recognizing determinants of self-antigens when tolerance has been reversed by aberrant self-antigen expression. As models, we have studied myeloid leukemia and MDS and have found that CD8 lymphocytes recognized the HLA-A2-restricted PR1 peptide, derived from both P3 and NE, due to aberrant subcellular localization and overexpression.
LEARNING OBJECTIVES
The Research Intern will receive training and conduct research at the broad intersection of cancer biology and immunology, which will help build a strong portfolio for their future career development. They will focus on gaining an understanding of immunotherapies for leukemia and other hematological diseases through an understanding of T-cell immunity against hematopoietic progenitors. They will perform hands-on experiments, engage in study design, and analyze data using advanced techniques. The Research Intern will attend lab meetings, journal clubs, and research seminars to enhance their critical thinking, experimental planning, and collaboration skills. Additionally, they will develop scientific communication proficiency through manuscript preparation and presentations, ultimately contributing to the advancement of cancer immunotherapy research. They will collaborate with various comprehensive cores at MDACC to develop novel therapeutic strategies that enhance targeted and immunotherapies. Additionally, they will also benefit from collaborations with Dr. Molldrem's former colleagues at various institutes.
Dr. Molldrem is deeply committed to the professional fulfillment and career advancement of all trainees and will operate with the primary goal of fostering career growth and development. Mentorship will be mutually planned and an individually tailored approach for each member of the team, and will also involve an extended committee of senior faculty members across multiple disciplinary fields to ensure full success. Together, we will work to create a successful training-and ultimately transition-plan in accordance with one's goals.
ELIGIBILITY REQUIREMENTS
Highly motivated individuals who have obtained or are about to obtain a bachelor's or master's degree. Degree must have been obtained recently (within one year). Applicant must have previous research experience. Individuals with excellent written and oral communication skills are required.
POSITION INFORMATION
07/31/2025
LEARNING OBJECTIVES
The Research Intern will receive training and conduct research at the broad intersection of cancer biology and immunology, which will help build a strong portfolio for their future career development. They will focus on gaining an understanding of immunotherapies for leukemia and other hematological diseases through an understanding of T-cell immunity against hematopoietic progenitors. They will perform hands-on experiments, engage in study design, and analyze data using advanced techniques. The Research Intern will attend lab meetings, journal clubs, and research seminars to enhance their critical thinking, experimental planning, and collaboration skills. Additionally, they will develop scientific communication proficiency through manuscript preparation and presentations, ultimately contributing to the advancement of cancer immunotherapy research. They will collaborate with various comprehensive cores at MDACC to develop novel therapeutic strategies that enhance targeted and immunotherapies. Additionally, they will also benefit from collaborations with Dr. Molldrem's former colleagues at various institutes.
Dr. Molldrem is deeply committed to the professional fulfillment and career advancement of all trainees and will operate with the primary goal of fostering career growth and development. Mentorship will be mutually planned and an individually tailored approach for each member of the team, and will also involve an extended committee of senior faculty members across multiple disciplinary fields to ensure full success. Together, we will work to create a successful training-and ultimately transition-plan in accordance with one's goals.
ELIGIBILITY REQUIREMENTS
Highly motivated individuals who have obtained or are about to obtain a bachelor's or master's degree. Degree must have been obtained recently (within one year). Applicant must have previous research experience. Individuals with excellent written and oral communication skills are required.
POSITION INFORMATION
07/31/2025
